Love as a Neurochemical Regulator: A Psychoneuroimmunological Perspective on Marriage, Divorce, and Impact of Energy 

Psychoneuroimmunology shows that love is not only an emotion but a biological regulator of the brain, hormones, and immune system. When love is emotionally secure and socially anchored, it stabilizes dopamine, serotonin, oxytocin, GABA, and cortisol, creating motivation, emotional balance, restful sleep, and immune strength. This is why marriage, at its best, represents the happiness chemistry of love—a regulated, life-building state that provides emotional safety, predictability, shared meaning, and nervous system stability.

As human evolution progresses, a person’s emotional frequency also evolves. With higher emotional stability, the body produces more calming chemistry such as serotonin, oxytocin, GABA, and balanced dopamine instead of stress-driven cortisol and adrenaline. When one partner evolves into calm regulation while the other remains locked in fear, control, anger, or impulsivity, their PNI signatures become biologically incompatible. In such cases, love may genuinely end at the old frequency and later restart with a partner whose emotional-neurochemical rhythm matches the evolved state. There can be no lasting happiness in a marriage when the PNI chemistry of both partners is mismatched.

Lust, in contrast, produces a sharp dopamine rise based on novelty, followed by a rapid neurochemical crash. Because emotional security is absent, serotonin does not stabilize and cortisol remains elevated. This is why casual intimacy often leads to anxiety, emptiness, disturbed sleep, depression, anger, emotional volatility, and feelings of rejection or humiliation. Love builds the nervous system; lust repeatedly strains it.

When love ends within a marriage, the relationship often shifts into neglect, betrayal, cheating, or chronic conflict. This sharply increases cortisol as the nervous system enters survival mode. Although separation or divorce may temporarily intensify stress, over time the brain can replace abuse-driven chemistry with calming neurotransmitters such as GABA and serotonin, restoring emotional balance and sleep—especially when financial and family conditions allow nervous system recovery. Staying in an abusive or loveless relationship continuously overstimulates stress chemistry and can lead to severe anxiety, depression, immune breakdown, psychosomatic illness, and even death through stress-related disease or suicide risk. From a PNI perspective, divorce can become a biological and psychological reset when love has truly ended.

From an evolutionary and clinical perspective, love is non-replaceable as long as it is supportive because it sustains emotional regulation, cooperation, resilience, and the will to live. Casual desire may excite the body like an addiction, but dopamine drops suddenly and triggers anger chemistry through glutamate, noradrenaline, adrenaline, cortisol, and testosterone.

PNI Formula for Anger

High Testosterone + High Adrenaline + High Noradrenaline + High Cortisol + Low Serotonin + Low GABA = Explosive Anger

PNI Formula for Love

High Oxytocin + Balanced Dopamine + High Serotonin + High GABA + Low Cortisol + Low Adrenaline
This creates emotional stability, secure attachment, empathy, deep sleep, immune balance, and motivation to live.

PNI Formula for Inner Peace

High GABA + High Serotonin + Low Cortisol + Low Noradrenaline + Balanced Dopamine + Stable Oxytocin

You cannot depend on medicines only as these chemicals have to be created in multitudes by the body through a repetitive emotional internal dominant focus with choosing to be positive , calm, stable, happy and healthy.

Love, when committed and emotionally safe, becomes protective, emotionally matched, and biologically aligned, stabilizing brain chemistry and sustaining life energy. Love is not sentimental—it is chemistry. It is a matching of vibrational frequencies at the psychoneuroimmunological level of the subconscious mind, a frequency we are born with and which evolves through life. Love is among the highest positive frequencies, along with happiness, joy, and peace.

Love lasts when both partners maintain inner positivity, match emotional frequencies, and focus on body chemistry rather than only rituals, which cannot create happiness if negativity dominates the mind. 

Love can also be nurtured through pets, plants, art, creativity, nature, and spirituality—all of which stabilize hormones and sustain happiness.

Love is not an emotion alone.
It is a biological survival system.
And for human well-being, it remains irreplaceable till it produces more positivity, security and happiness than trifles, abuse or loss of self worth.